Journal
SCIENCE
Volume 299, Issue 5607, Pages 697-700Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1079190
Keywords
-
Categories
Funding
- NIDDK NIH HHS [Z01 DK015600-10] Funding Source: Medline
Ask authors/readers for more resources
Sex chromosomes are primary determinants of sexual dimorphism in many organisms. These chromosomes are thought to arise via the divergence of an ancestral autosome pair and are almost certainly influenced by differing selection in mates and females. Exploring how sex chromosomes differ from autosomes is highly amenable to genomic analysis. We examined global gene expression in Drosophila melanogaster and report a dramatic underrepresentation of X-chromosome genes showing high relative expression in mates. Using comparative genomics, we find that these same X-chromosome genes are exceptionally poorly conserved in the mosquito Anopheles gambiae. These data indicate that the X chromosome is a disfavored location for genes selectively expressed in males.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available