Journal
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
Volume 84, Issue 2, Pages 153-160Publisher
W B SAUNDERS CO
DOI: 10.1053/apmr.2003.50093
Keywords
brain injuries; outcome assessment (health care); rehabilitation
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Funding
- ODCDC CDC HHS [U17/CCU812447-06] Funding Source: Medline
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Objective: To identify potential sources of selection bias created by subjects lost to follow-up in studies of traumatic brain injury (TBI). Design: Demographic, premorbid, injury-related, and hospital course characteristics were compared for subjects lost and found for 1- and 2-year postinjury follow-ups by using bivariate tests and logistic regression analysis. Setting: Three prospective, longitudinal data sets-a single center, a multicenter, and a statewide incidence surveillance system and follow-up registry. Participants: Adolescents and adults hospitalized with a diagnosis of TBI. Interventions: Not applicable. Main Outcome Measures: Subjects were considered lost when no information was collected from the person with TBI or only limited information could be obtained from a proxy, for any reason, including death, refusal, inability to locate, and inability to interview. Results: At year 1 follow-up, 58.0% to 58.6% of subjects were found; 39.7% to 42.0% of subjects were found by year 2. Variables most frequently associated with loss to follow-up were cause of injury, blood alcohol level, motor function, hospital payer source, and race and ethnicity. Conclusions: TBI follow-up studies may experience selective attrition of subjects who (1) are socioeconomically disadvantaged, (2) have a history of substance abuse, and (3) have violent injury etiologies. These phenomena are mitigated for those with more severe motor deficits. Loss to follow-up may be a problem inherent to this population; however, the high rate and its selective nature are problematic for outcome studies.
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