Journal
JOURNAL OF NEUROLOGY
Volume 250, Issue 2, Pages 222-225Publisher
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s00415-003-0983-6
Keywords
Creutzfeldt-Jakob disease; diffusion-weighted imaging; brain; MR imaging
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The definitive diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is based on brain autopsy. The 14-3-3 analysis in the CSF is considered a highly sensitive and specific procedure. Sensitivity, specificity and accuracy of EEG, the 14-3-3 assay and MR imaging in 12 patients referred for suspected sCJD were calculated. We suggest that diffusion-weighted MR imaging (DWI) should be included in the array of diagnostic tests because of the 100 % sensitivity and specificity.
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