Charge-coupled device speckle observations of binary stars with the WIYN Telescope. V. Measures during 2001-2006

A total of 1067 speckle observations of 345 binary stars are presented. Of these, 161 are double stars first resolved by Hipparcos, 17 are resolved for the first time in the observations presented here, and 21 are stars previously discovered by our program and reported in earlier papers in the series. In 947 cases, a magnitude difference is reported along with the relative astrometry. When comparing to systems with very well-known orbits, we find that the root mean square (rms) deviation in separation residuals is 2.81 +/- 0.28 mas, and the rms deviation in position angle residuals is 0.88 +/- 0.07 degrees. The magnitude difference measures show no significant deviation from Hipparcos photometry, and have average standard deviation of approximately 0.10 mag as judged from repeat observations. Five important systems discovered by Hipparcos are discussed.