Journal
AMERICAN JOURNAL OF KIDNEY DISEASES
Volume 41, Issue 2, Pages 493-496Publisher
W B SAUNDERS CO
DOI: 10.1053/ajkd.2003.50061
Keywords
cyclosporin A (CyA); Xenical; drug interaction; C-2 monitoring; pharmacokinetics; transplantation
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An overweight 56-year-old type II diabetic on peritoneal dialysis (body mass index 35 kg/m(2)) was taking Orlistat for some months up until live-unrelated renal transplantation. Despite oral cyclosporin A (CyA) for 48 hours pretransplantation, it was very difficult to achieve adequate CyA blood levels for the first week postengraftment despite the use of much larger oral CyA doses. After opening his bowels on day 7, and the use of 3 days intravenous CyA, good CyA blood levels were achieved then maintained with conventional oral doses. The authors believe that this case shows important interactions between CyA and Orlistat.
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