Journal
EUROPEAN JOURNAL OF CANCER
Volume 39, Issue 3, Pages 300-308Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0959-8049(02)00672-X
Keywords
breast cancer; randomised trial; elderly; mastectomy; wide excision; tamoxifen
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Funding
- NCI NIH HHS [2U10CA11488-31, 5U10CA11488-15] Funding Source: Medline
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We have examined the outcome of older patients with operable breast cancer treated in a randomised trial by either standard surgery or less extensive surgery and tamoxifen. There were 236 participants aged greater than or equal to70 years, randomised to either modified radical mastectomy MRM (n = 120) or wide local excision (WLE) and tamoxifen (T) 20 mg daily (n = 116). Survival curves were estimated using the Kaplan-Meier method and multivariate analyses were performed using Cox's proportional hazards model. Endpoints were survival and time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. No significant difference was seen in terms of progression-free survival, but there were significantly more loco-regional relapses in the WLE + T group. In contrast, there were more distant metastases in the MRM group, but with a similar overall survival in both groups. The results of this trial give cautious support for the use of WLE + T for selected older women. (C) 2003 Elsevier Science Ltd. All rights reserved.
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