Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 26, Issue 2, Pages 271-273Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.26.271
Keywords
Prunus persica seed; cancer chemoprevention; amygdalin-related glycoside; benzyl beta-gentiobioside; EBV-EA induction; mouse skin two-stage carcinogenesis
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Funding
- NCI NIH HHS [CA 17625] Funding Source: Medline
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Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallo-catechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic. position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN
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