Crystal structure of the copper(II) ternary complex of N-salicylidene-L-serinato with 2,6-diaminopyridine.: Toxicity studies against Drosophila melanogaster

The ternary [Cu(Sal-(L-Ser))(2,6-diaminopyridine)H2O] (1b) complex has been prepared and the crystal structure determined. The copper(II) cation has a square pyramidal geometry, being coordinated to the tridentate Sal-(L-Ser) Schiff base ligand and the heterocyclic nitrogen atom N(I 1) of the 2,6-diaminopyridine molecule which occupying the corners of the square base. The coordination sphere about the copper is completed by an axial O(W) atom of a water molecule. Spectroscopic data are discussed. Preliminary toxicity studies [larva-to-adult viability (V) and developmental time (in days) (DT)] of several copper(II) compounds including complex I and other related previously described complexes [Cu(Sal-(L-Ser))H2O].H2O (2) and [Cu(Sal-Ser)(2-aminopyridine)] (3) against Drosophila melanogaster (Or-R) show that these copper(II) complexes display less toxicity than simple copper(II) salts. (C) 2002 Elsevier Science Ltd. All rights reserved.