Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 1, Pages 75-81Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(02)00010-9
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During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.
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