Journal
ATHEROSCLEROSIS
Volume 166, Issue 2, Pages 203-212Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0021-9150(02)00202-2
Keywords
coronary heart disease; hormone replacement therapy; women; risk factors
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Coronary heart disease (CHD) is the leading cause of death in women. Epidemiologic, mechanistic, and animal-model studies have produced convincing evidence that hormone replacement therapy (HRT) could substantially decrease rates of CHD in women. However, several randomized clinical trials of HRT in women with CHID have been unable to confirm the earlier suggestions of benefit, and there has even been a suggestion of increased CHD risk. This article will review the findings to date of these long-term randomized clinical trials of HRT for prevention or treatment of CHD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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