Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 23, Issue 1, Pages 65-+Publisher
W B SAUNDERS CO
DOI: 10.1016/S0889-8561(02)00074-7
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Funding
- NCI NIH HHS [CA 20408] Funding Source: Medline
- NIAMS NIH HHS [N01 AR 6-2224] Funding Source: Medline
- NIA NIH HHS [R01 AG 16653] Funding Source: Medline
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Autoimmune disease in the elderly is hypothesized to be caused by an imbalance in T-cell expansion and deletion after all encounter with self-antigens. A decrease in thymic Output leads to a decreased pool of naive T cells in the periphery and to increased oligoclonal expansion of T cells. This expansion may be Caused by Stimulation with autoantigens that drive high-affinity interactions with self-antigens. Accumulation of presenescent, apoptosis-resistant, and proinflammatory T cells results in the growth of these autoreactive T cells. A decreased T-cell activation response that occurs with age leads to several defects that diminish the immune response.
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