Journal
GENES & DEVELOPMENT
Volume 17, Issue 3, Pages 330-335Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.1046203
Keywords
heterochromatm; DNA replication; timing; centromere; telomere; mating type
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Funding
- NCI NIH HHS [CA84302, CA095908, P30 CA16056-26, R01 CA095908, P30 CA016056] Funding Source: Medline
- PHS HHS [49294] Funding Source: Medline
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Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast, Schizosaccharomyces pombe. We found that heterochromatic centromeres and silent mating-type cassettes replicate in early S phase. Only heterochromatic telomeres replicate in late S phase. Research in other laboratories has shown that occasionally other organisms also replicate some of their heterochromatin in early S phase. Thus, late replication is not an obligatory feature of heterochromatin.
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