Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 51, Issue 2, Pages 313-316Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkg090
Keywords
caspofungin; calcineurin inhibitors
Funding
- NCI NIH HHS [CA16672] Funding Source: Medline
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Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.
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