Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 13, Issue 1, Pages 130-139Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(03)00013-7
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM 10831, GM 63539] Funding Source: Medline
Ask authors/readers for more resources
For many protein families, such as serine proteinases or serine proteinase inhibitors, the family assignment predicts reactivity only in general terms. Both detailed specificity and quantitative reactivity are lacking. We believe that, for many such protein families, algorithms can be devised by defining the subset of n functionally important sequence positions, making the 19n possible single mutants and measuring their reactivity. Given the assumption that the contributions of the n positions are additive, the reactivities of the 20(n) variants can be predicted. This is illustrated by an almost complete algorithm for the Kazal family of protein inhibitors of serine proteinases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available