Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 30, Issue 2, Pages 159-168Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0969-8051(02)00419-5
Keywords
colitis; liposomes; inflammatory bowel disease; indium-111; technetium-99m; inflammation; drug delivery
Funding
- NHLBI NIH HHS [R01 HL 53052] Funding Source: Medline
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[Tc-99m] liposomes (TL) and [In-111]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [Tc-99m] liposomes than the normal colon whereas the ratio was only 15.2 in case of [In-111] WBCs. The study demonstrates the usefulness of [Tc-99m] liposomes for imaging inflammatory bowel diseases. (C) 2003 Elsevier Science Inc. All rights reserved.
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