Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 2, Pages 255-258Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np020455x
Keywords
-
Ask authors/readers for more resources
A methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N-G-monomethyl-L-arginine (L-NMMA), and 1 displayed the strongest activity with an IC50 value of 6.4 muM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available