Journal
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
Volume 17, Issue 1, Pages 47-61Publisher
ELSEVIER SCI LTD
DOI: 10.1053/bega.2002.0344
Keywords
bacterial flora; inflammatory bowel disease; probiotics; antibiotics; Crohn's disease; ulcerative colitis; pouchitis
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In this chapter we summarize the clinical and experimental data which indicate that bacteria, especially from the endogenous microflora, play a role in the pathogenesis of Crohn's disease, ulcerative colitis and pouchitis. We review the clinical trials, focusing on randomized controlled trials which used antibiotics or probiotics to treat situations of IBD or prevent recurrence, and we discuss the future of this approach.
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