Determinants of left atrial size in patients with newly diagnosed untreated hypertension

The present study determined the relationships between ambulatory blood pressure, left ventricular mass, body mass index, and other clinical and demographic variables to left atrial size in previously untreated hypertensive and normotensive subjects. Left atrial size was measured unidimensionally using M-mode echocardiography in 58 newly diagnosed never-treated hypertensive patients (office blood pressure 149/96 +/- 15/7 mmHg) and 28 normotensive control subjects (office blood pressure, 122/78 +/- 8/8 mmHg). Left ventricular mass, septal and posterior wall thickness were significantly increased in hypertensive compared to normotensive subjects (230 +/- 63 g versus 181 +/- 45 g, 1.1 +/- 0.2 cm versus 0.94 +/- 0.2 cm, and 1.04 +/- 0.2 cm versus 0.92 +/- 0.2 cm respectively; all p < 0.001). Left ventricular internal diameter (4.9 +/- 0.6 versus 4.8 +/- 0.4 cm, p = 0.54) and left atrial size (3.74 +/- 0.48 versus 3.70 +/- 0.34 cm, p = 0.86) were not different between the two groups respectively. Body mass index, weight, left ventricular mass, wall thickness, and 24-h pulse pressure were significant correlates of left atrial size in the entire group and in the hypertensive subgroup. In the normotensive subgroup, body weight, body mass index, 24-h systolic and pulse pressure, and left ventricular mass were significant correlates. Multiple regression analyses in the entire group and the hypertensive subgroup alone showed that body mass index and left ventricular mass were the two best predictors of left atrial dimension. These data demonstrate that body mass index and left ventricular mass were the main correlates of left atrial size in patients with previously untreated stage I-II hypertension.