Journal
SEMINARS IN IMMUNOLOGY
Volume 15, Issue 1, Pages 23-32Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044-5323(02)00125-2
Keywords
multiple sclerosis; EAE; CCL2/MCP-1; CCP2
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Funding
- NINDS NIH HHS [P01 NS 38667, R01 NS 32151] Funding Source: Medline
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Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human central nervous system (CNS). In MS, CNS inflammation is associated with demyelination and axonal degeneration, which leads to clinical presentation. Expression and cellular localization of CCL2/MCP-1 and CCR2 in MS have been described in the three compartments: brain. cerebrospinal fluid (CSF) and blood. Evidence from descriptive, transgenic. knockout and neutralizing studies of experimental autoimmune encephalomyelitis (EAE) points towards a nonredundant role of CCL2 and CCR2 in the recruitment of inflammatory infiltrate into the CNS. Hence, CCL2 and CCR2 may be targets for specific and effective treatment in MS. (C) 2003 Elsevier Science Ltd. All rights reserved.
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