Journal
ACTA NEUROLOGICA SCANDINAVICA
Volume 107, Issue 2, Pages 106-109Publisher
WILEY
DOI: 10.1034/j.1600-0404.2003.01365.x
Keywords
intracerebral haemorrhage; apolipoprotein E; survival; outcome
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Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.
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