Journal
ANNALS OF THORACIC SURGERY
Volume 75, Issue 2, Pages S700-S708Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0003-4975(02)04700-8
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Funding
- NHLBI NIH HHS [R01HL66132, R01HL34759] Funding Source: Medline
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Although the mechanisms underlying ischemia/ reperfusion injury remain elusive, evidence supports the etiologic role of intracellular calcium overload and oxidative stress induced by reactive oxygen species. Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium accumulation. Inhibition of the NHE-1 isoform may attenuate the consequences of this injury. Although there is strong preclinical and early clinical evidence that NHE inhibitors may be cardioprotective, definitive proof of this concept in humans awaits the results of ongoing clinical trials. (C) 2003 by The Society of Thoracic Surgeons.
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