Journal
ASN NEURO
Volume 6, Issue 4, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1759091414544472
Keywords
FUS/TLS; amyotrophic lateral sclerosis; DNA damage repair; stress response; RNA processing; stress granules
Categories
Funding
- NIH/NINDS [R01NS078145, R01NS067206]
- ALS Association
- ALS Therapy Alliance/CVS Pharmacy
- Worcester Foundation
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Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. FUS was initially identified as a fusion oncoprotein, and thus, the early literature focused on the role of FUS in cancer. With the recent discoveries revealing the role of FUS in neurodegenerative diseases, namely amyotrophic lateral sclerosis and frontotemporal lobar degeneration, there has been a renewed interest in elucidating the normal functions of FUS. It is not clear which, if any, endogenous functions of FUS are involved in disease pathogenesis. Here, we review what is currently known regarding the normal functions of FUS with an emphasis on DNA damage repair, RNA processing, and cellular stress response. Further, we discuss how ALS-causing mutations can potentially alter the role of FUS in these pathways, thereby contributing to disease pathogenesis.
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