Journal
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Volume 56, Issue 1, Pages 11-18Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/mp.56.1.11
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Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.
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