Journal
MECHANISMS OF DEVELOPMENT
Volume 120, Issue 2, Pages 253-265Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00419-7
Keywords
mitosis; string; neural determination; quiescence; G2 arrest; notch; proneural; cell cycle
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In the wing discs of Drosophila, the mecanosensory precursor cells are singled out from clusters of cells blocked at the G2 phase of the cell cycle. This mitotic quiescence and the selection of the precursors are under strict spatio-ternporal control. We forced G2 cells to enter mitosis by overexpression of string, the Drosophila homologue of the cdc25 gene. Premature entrance in the cell cycle is associated to a loss of precursor cells. Precursors are lost consecutively to a transcriptional down-regulation of the determinant proneural achaete/scute genes. This down-regulation results from an over-activation of the Enhancer of Split genes, known as effectors of the Notch signalling pathway. We conclude that exit from the cell cycle is required for proper neural cell fate determination. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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