Journal
ASN NEURO
Volume 5, Issue 3, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1042/AN20130025
Keywords
axon-glial interactions; ion channel; neurological disease; node of Ranvier
Categories
Funding
- National Multiple Sclerosis Society
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Dysfunction and/or disruption of nodes of Ranvier are now recognized as key contributors to the pathophysiology of various neurological diseases. One reason is that the excitable nodal axolemma contains a high density of Nav (voltage-gated Na+ channels) that are required for the rapid and efficient saltatory conduction of action potentials. Nodal physiology is disturbed by altered function, localization, and expression of voltage-gated ion channels clustered at nodes and juxtaparanodes, and by disrupted axon-glial interactions at paranodes. This paper reviews recent discoveries in molecular/cellular neuroscience, genetics, immunology, and neurology that highlight the critical roles of nodes of Ranvier in health and disease.
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