Journal
ASN NEURO
Volume 3, Issue 4, Pages 183-193Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1042/AN20110011
Keywords
fusion; glioblastoma multiforme; glioma; macrophage; microglia; phagocytosis
Categories
Funding
- National Institutes of Health [HD-39722, NS- 55195, CA-102135]
- American Institute of Cancer Research
- Boston College
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD039722] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA102135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI027763] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS055195, R56NS055195] Funding Source: NIH RePORTER
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Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macrophages). These types of cells are thought to either enhance or inhibit brain tumour progression. Recent evidence indicates that neoplastic cells with macrophage characteristics are found in numerous metastatic cancers of non-CNS (central nervous system) origin. Evidence is presented here suggesting that sub-populations of cells within human gliomas, specifically GBM (glioblastoma multiforme), are neoplastic macrophages/microglia. These cells are thought to arise following mitochondrial damage in fusion hybrids between neoplastic stem cells and macrophages/microglia.
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