Related references
Note: Only part of the references are listed.Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
Jason P. Covy et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The function of ROCO proteins in health and disease
Patrick A. Lewis
BIOLOGY OF THE CELL (2009)
Investigation of leucine-rich repeat kinase 2
Vasanti S. Anand et al.
FEBS JOURNAL (2009)
The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
Cherry Cheng-Ying Ho et al.
JOURNAL OF NEUROSCIENCE (2009)
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
Jeanne C. Latourelle et al.
BMC MEDICINE (2008)
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2
Jose Bras et al.
BMC NEUROLOGY (2008)
Structure of the Roc-COR domain tandem of C-tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
Katja Gotthardt et al.
EMBO JOURNAL (2008)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
LRRK2 regulates synaptic vesicle endocytosis
Narae Shin et al.
EXPERIMENTAL CELL RESEARCH (2008)
The Roco protein family:: a functional perspective
Ignacio Marin et al.
FASEB JOURNAL (2008)
Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls
Coro Paisan-Ruiz et al.
HUMAN MUTATION (2008)
Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC
Wouter N. van Egmond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
Elisa Greggio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
LRRK2 mutation in familial Parkinson's disease in a Taiwanese population:: clinical, PET, and functional studies
Chin-Hsien Lin et al.
JOURNAL OF BIOMEDICAL SCIENCE (2008)
Ancient origin of the Parkinson disease gene LRRK2
Ignacio Marin
JOURNAL OF MOLECULAR EVOLUTION (2008)
LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients
Daniel Kam Yin Chan et al.
JOURNAL OF NEURAL TRANSMISSION (2008)
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
Edward D. Plowey et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
Lizhen Wang et al.
JOURNAL OF NEUROSCIENCE (2008)
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
Payal N. Gandhi et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study
Mary M. Hulihan et al.
LANCET NEUROLOGY (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
Danling Wang et al.
MOLECULAR NEURODEGENERATION (2008)
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
Anthony K. F. Liou et al.
NEUROBIOLOGY OF DISEASE (2008)
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
K. Haugarvoll et al.
NEUROLOGY (2008)
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Junpeng Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The G2019S LRRK2 mutation in Brazilian patients with Parkinson's disease:: Phenotype in monozygotic twins
Renato P. Munhoz et al.
MOVEMENT DISORDERS (2008)
Dynamic and redundant regulation of LRRK2 and LRRK1 expression
Saskia Biskup et al.
BMC NEUROSCIENCE (2007)
The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease -: Is there a gender effect?
A. Orr-Urtreger et al.
NEUROLOGY (2007)
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
Luxuan Guo et al.
EXPERIMENTAL CELL RESEARCH (2007)
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
Berta Luzon-Toro et al.
HUMAN MOLECULAR GENETICS (2007)
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
H. L. Melrose et al.
NEUROSCIENCE (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1
Elisa Greggio et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
Sung Bae Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal
Joaquim J. Ferreira et al.
MOVEMENT DISORDERS (2007)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Patrick A. Lewis et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Apoptotic mechanisms in mutant LRRK2-mediated cell death
Ciro Iaccarino et al.
HUMAN MOLECULAR GENETICS (2007)
G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies
Carles Gaig et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)
LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins
Aisa Sakaguchi-Nakashima et al.
CURRENT BIOLOGY (2007)
Leucine-rich repeat kinase 2 associates with lipid rafts
Taku Hatano et al.
HUMAN MOLECULAR GENETICS (2007)
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
NATURE (2007)
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
Genta Ito et al.
BIOCHEMISTRY (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia
Matthew J. Farrer et al.
PARKINSONISM & RELATED DISORDERS (2007)
Identification of potential protein interactors of Lrrk2
Justus C. Daechsel et al.
PARKINSONISM & RELATED DISORDERS (2007)
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families
Lianna Ishihara et al.
MOVEMENT DISORDERS (2007)
Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease
Nathan Pankratz et al.
MOVEMENT DISORDERS (2006)
The Parkinson disease gene LRRK2:: Evolutionary and structural insights
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION (2006)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East:: Evidence of two distinct founding events beginning two millennia ago
Cyrus P. Zabetian et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
Genetics of Parkinson's disease and parkinsonism
John Hardy et al.
ANNALS OF NEUROLOGY (2006)
Clinical heterogeneity of the LRRK2 G2019S mutation
Spiridon Papapetropoulos et al.
ARCHIVES OF NEUROLOGY (2006)
Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease
C. P. Zabetian et al.
NEUROLOGY (2006)
Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease
Roberta Marongiu et al.
MOVEMENT DISORDERS (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia
Rachel Saunders-Pullman et al.
NEUROSCIENCE LETTERS (2006)
LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain
D Korr et al.
CELLULAR SIGNALLING (2006)
Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort
CH Williams-Gray et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)
LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease
J Infante et al.
NEUROSCIENCE LETTERS (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease
MR Cookson et al.
CURRENT OPINION IN NEUROLOGY (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
G2019S LRRK2 mutation in French and North African families with Parkinson's disease
S Lesage et al.
ANNALS OF NEUROLOGY (2005)
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor -: art. no. e65
S Goldwurm et al.
JOURNAL OF MEDICAL GENETICS (2005)
LRRK2 gene in Parkinson disease -: Mutation analysis and case control association study
C Paisán-Ruíz et al.
NEUROLOGY (2005)
A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
CP Zabetian et al.
NEUROLOGY (2005)
Escaping Parkinson's disease:: A neurologically healthy octogenarian with the LRRK2 G2019S mutation
DM Kay et al.
MOVEMENT DISORDERS (2005)
LRRK2 R1441G in Spanish patients with Parkinson's disease
IF Mata et al.
NEUROSCIENCE LETTERS (2005)
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
M Funayama et al.
ANNALS OF NEUROLOGY (2005)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
The PARK8 locus in autosomal dominant parkinsonism: Confirmation of linkage and further delineation of the disease-containing interval
A Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Roc, a Ras/GTPase domain in complex proteins
L Bosgraaf et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1
M Funayama et al.
ANNALS OF NEUROLOGY (2002)