Journal
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Volume 27, Issue 2, Pages 177-185Publisher
WILEY
DOI: 10.1097/01.ALC.0000051022.26489.CF
Keywords
kudzu; St. John's Wort; daidzin; NPI-031G; alcohol-preferring rats and hamsters; alcohol intake; mitochondrial aldehyde dehydrogenase; benzodiazepine & 5-HT2C receptors
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This review summarizes the findings of the effects on alcohol intake in alcohol-preferring rats of extracts or purified compounds from two of the most promising herbs: kudzu (Pueraria lobata) and St. John's Wort (Hypericum perforatum). It is a summary of a symposium presented at the 2002 RSA meeting in San Francisco. The meeting organizers/co-chairs were David Overstreet and Wing-Ming Keung. The presentations were (1) Introduction to the symposium, by David Y. W. Lee and David H. Overstreet; (2) Effects of daidzin on alcohol intake-search for mechanisms of action, by Wing-Ming Keung; (3) Long-term suppressive effects of puerarin on alcohol drinking in rats, by David Overstreet and David Y. W. Lee; (4) St. John's Wort extract reduces alcohol intake in FH and P rats, by Amir Rezvani and David Overstreet and (5) Hypericum perforatum extracts reduce alcohol intake in Marchigian Sardinian alcohol-preferring rats, by Maurizio Massi.
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