Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 3, Pages 2287-2294Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.3.2287-2294.2003
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Funding
- NIAID NIH HHS [R01 AI43453, R01 AI043453] Funding Source: Medline
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Hepatitis B virus assembly begins with the packaging of an RNA pregenome into intracellular nucleocapsids, with subsequent reverse transcription within these nucleocapsids converting the RNA into a characteristic, partially double-stranded DNA, which, alone, is found in enveloped extracellular virions as the viral genome. Using a synchronized replication system for the duck hepatitis B virus, together with a stringent two-step assay for virion secretion, we demonstrate that this selective genome secretion results from an intrinsic secretion competence gained only by the nucleocapsids at the late stage of reverse transcription.
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