Journal
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Volume 29, Issue 1, Pages 123-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/S0889-857X(02)00098-4
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- NIAID NIH HHS [R01 AI 48079] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 49221] Funding Source: Medline
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Endogenous retroviruses (ERVs) correspond to the integrated proviral form of infectious retroviruses that are trapped within the genome by mutations. Endogenous retroviruses represent a key molecular link between the host genome and infectious viral particles. Proteins encoded by ERVs are recognized by antiviral immune responses and become targets of autoreactivity. Activation of ERVs, such as human ERV-K or a human T-cell lymphotropic virus-related endogenous sequence, may also mediate pathogenicity of Epstein-Barr virus. Endogenous retrovirus peptides can directly regulate immune responses. Thus, molecular mimicry and immunomodulation by ERVs may account for self-reactivity and abnormal T- and B-cell functions in autoimmune disorders.
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