Journal
DEVELOPMENTAL DYNAMICS
Volume 226, Issue 2, Pages 202-210Publisher
WILEY
DOI: 10.1002/dvdy.10220
Keywords
zebrafish; wound healing; regeneration; fin; limb; blastema; fgf; Shh
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Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. To address this deficiency, we and others have focused on the zebrafish model system. Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins. (C) 2003 Wiley-Liss, Inc.
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