Journal
SEMINARS IN LIVER DISEASE
Volume 23, Issue 1, Pages 21-37Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2003-37586
Keywords
liver; hepatitis B virus; T cell; immune response; cytokine
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Hepatitis B virus infection is one of the most frequent causes of chronic liver disease worldwide. Even though a preventive vaccine is available, the search for a cure for chronically infected patients remains a high priority to reduce the morbidity and mortality from liver cirrhosis and hepatocellular carcinoma. This review summarizes the immune response in acute, self-limited and chronic hepatitis B; its differential effects on viral replication and liver injury; and prospects for immunotherapy.
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