Journal
NATURE STRUCTURAL BIOLOGY
Volume 10, Issue 2, Pages 141-145Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsb888
Keywords
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Funding
- NIGMS NIH HHS [R01 GM049650, R37 GM049650] Funding Source: Medline
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Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs.
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