Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 27, Issue 1, Pages 15-19Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0278-5846(02)00309-3
Keywords
electroconvulsive therapy; major depression; orbitomeatal line; regional cerebral blood flow
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Decreased cerebral blood flow is documented in depression. In this study, 15 patients were studied with Tc-99m-HMPAO SPECT before and after a course of electroconvulsive therapy (ECT). Improvement in frontal and temporal hypoperfusion was seen only in those patients who responded to ECT. Cerebral hypoperfusion may be a state-dependent marker in depressive illness. (C) 2002 Elsevier Science Inc. All rights reserved.
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