Journal
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
Volume 87, Issue 2, Pages 1293-1309Publisher
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201520140704
Keywords
Fungal Infections; Cryptococcus; meningitis; meningoencephalitis
Categories
Funding
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Instituto Nacional de Ciencia e Tecnologia de Inovacao em Doencas Negligenciadas (INCT-IDN)
- Wellcome Trust (UK)
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Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.
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