Journal
PEPTIDES
Volume 24, Issue 2, Pages 325-328Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(03)00044-5
Keywords
rubiscolin; Rubisco; delta opioid peptide; memory consolidation; passive avoidance test
Ask authors/readers for more resources
Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3 nmol/mouse after intracerebroventricular administration, and at 100 mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor. (C) 2003 Elsevier Science Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available