Journal
TRENDS IN GENETICS
Volume 19, Issue 2, Pages 97-106Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(02)00033-1
Keywords
-
Categories
Ask authors/readers for more resources
The biological basis of late-onset disease has been shaped by genetic factors subject to varying degrees of evolutionary constraint. Late-onset traits are not only more sensitive to environmental variation, owing to the breakdown of homeostatic mechanisms, but they also show higher levels of genetic variation than traits directly influencing reproductive fitness. The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available