Journal
JOURNAL OF ANTIBIOTICS
Volume 69, Issue 1, Pages 51-56Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2015.72
Keywords
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [109S361]
- Scientific Research Foundation of Ege University [10-FEN-012]
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Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional (H-1 and C-13) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.
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