Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 3, Pages 1334-1339Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0335785100
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Funding
- NEI NIH HHS [R01EY06039, R01 EY006039] Funding Source: Medline
- NINDS NIH HHS [R01NS32290] Funding Source: Medline
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The membrane-associated guanylate kinase PSD-95 scaffolds N-methyl-(D)-aspartate receptors to cytoplasmic signaling molecules, and associates with other glutamate receptors at central synapses. However, regulation of PSD-95 in vivo is poorly understood. We provide evidence of an activity-dependent redistribution of PSD-95 to dendrites in central visual neurons that is tied to eye opening. Six hours after eye opening, increased dendritic PSD-95 coimmunoprecipitates with the same proportions of stargazin, increased proportions of the N-methyl-(D)-aspartate receptor subunit NR2A, and decreased proportions of NR2B. Sustained high levels of PSD-95 in dendrites are dependent on continued pattern vision in juvenile but not mature animals, suggesting that the stabilization of PSD-95 at synapses may be involved in the control of developmental plasticity.
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