Journal
JOURNAL OF ANTIBIOTICS
Volume 68, Issue 11, Pages 703-706Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2015.55
Keywords
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Funding
- National Key Basic Research Program of China (973)'s Project [2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- National Natural Science Foundation of China [31270402, 21172230, 41476135, 41376162, 41406187]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001]
- Guangzhou Scientific Research Project [2014J4100212]
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A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against He La, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 mu M, respectively.
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