Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 3, Pages 1158-1160Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo026407z
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A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by extraction or filtration.
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