Journal
JOURNAL OF ANTIBIOTICS
Volume 68, Issue 9, Pages 586-590Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2015.36
Keywords
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Funding
- Agence Nationale de la Recherche (CEBA) [ANR-10-LABX-0025]
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Chrysoporthe sp. SNB-CN74 was isolated from a Nasutitermes corniger nest, and its ethyl acetate extract was found to exhibit very strong antibacterial activity. Two antibacterial metabolites were isolated, (-)-R- skyrin (2) and (+)-rugulosin A (3). Eventually, the fungus lost its antibiotic potential when subcultured, and the use of yeast extract induced the re-expression of these two antibiotics. Yeast extract possibly activated a cryptic pathway by mimicking the presence of an ecological competitor.
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