Journal
BRAIN RESEARCH
Volume 963, Issue 1-2, Pages 274-281Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)04048-9
Keywords
helpless rat; habenula; ventral tegmental area; depression; genetic predisposition to disease; metabolism; cytochrome oxidase
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Funding
- NIMH NIH HHS [T32 MH18837] Funding Source: Medline
- NINDS NIH HHS [R01 NS37755] Funding Source: Medline
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Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related interpeduncular nucleus. In contrast, helpless rats had 28% reduced metabolism in the ventral tegmental area (VTA) and 14-16% reductions in the basal ganglia and basolateral and central amygdala. The opposite metabolic changes in the habenula and ventral tegmental area may be especially important for determining the congenitally helpless rat's global pattern of brain activity, which resembles the metabolic activity pattern produced by dopamine antagonism. (C) 2002 Elsevier Science B.V. All rights reserved.
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