Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 278, Issue 7, Pages 5214-5226Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M206621200
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- Cancer Research UK [A3585] Funding Source: Medline
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were identified adjacent to the LMP/TAP gene cluster in the human and mouse major histocompatibility complex class II region. These sequences were shown to function as nuclear matrix attachment regions (MARs). Three of the five human MARs and the single mouse MAR recruit heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) in vivo during transcriptional up-regulation of the major histocompatibility complex class 11 genes. The timing of this recruitment correlates with a rise in mature TAP1 mRNA. Two of the human NLARs bind hnRNP-A1 in vitro directly within a 35-bp sequence that shows over 90% similarity to certain Alu repeat sequences. This study shows that MARs recruit and bind hnRNP-A1 upon transcriptional up-regulation.
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