Journal
BIOCHEMICAL JOURNAL
Volume 370, Issue -, Pages 29-34Publisher
PORTLAND PRESS
DOI: 10.1042/BJ20021539
Keywords
Abl; ArgBP2; Cbl; degradation; tyrosine kinase; ubiquitination
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The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.
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