Journal
GENES & DEVELOPMENT
Volume 17, Issue 4, Pages 443-448Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1060703
Keywords
carcinogenesis; mutator genes; DNA repair; spontaneous DNA damage; C. elegans
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Funding
- Wellcome Trust [054523] Funding Source: Medline
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An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly conserved from yeast to human. Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology.
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