Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1593, Issue 2-3, Pages 115-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4889(02)00349-X
Keywords
zyxin; paxillin; focal adhesion; LIM domain; nuclear-cytoplasmic shuttling; transcription
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Funding
- NCI NIH HHS [CA47763] Funding Source: Medline
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Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects. (C) 2002 Elsevier Science B.V. All rights reserved.
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