4.8 Article

Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation.: A comparative rate study

Journal

ORGANIC LETTERS
Volume 5, Issue 4, Pages 475-478

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol027457t

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[GRAPHICS] Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of alpha- or beta-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.

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