Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Volume 1625, Issue 3, Pages 291-295Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4781(02)00628-0
Keywords
dolichol biosynthesis; glycosyl carrier lipid; dehydrodolichyl diphosphate synthase; cis-prenyl chain elongation
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We isolated a cDNA encoding human dehydrodolichyl diphosphate (Dedol-PP) synthase and expressed the gene in a yeast mutant strain SNH23-7D, which is deficient in Dedol-PP synthase activity. The identity of the cloned enzyme was confirmed by functional complementation of SNH23-7D strain together with in vitro Dedol-PP synthase activity assay. Northern blot analysis indicated that testis and kidney expressed Dedol-PP synthase mRNA at high levels. (C) 2003 Elsevier Science B.V. All rights reserved.
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