Journal
CELL
Volume 112, Issue 4, Pages 441-451Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(03)00082-5
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM58065] Funding Source: Medline
Ask authors/readers for more resources
Macromolecular transport between the cytoplasm and the nucleus occurs through the nuclear pore complex (NPC) and is mediated by multiple families of soluble transport factors. All these transport factors share the ability to translocate across the NPC through specific interactions with components of the nuclear pore. This review highlights advances in our understanding of the structure and function of the NPC and the shuttling transport receptors involved in nuclear transport. It discusses recently proposed models for the translocation of receptor-cargo complexes through the NPC channel and reviews how the small GTPase Ran functions as a positional marker of the genome to regulate multiple important aspects of the eukaryotic cell cycle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available